Stem cells in development of therapeutics for Parkinson's disease: A perspective
Identifieur interne : 000C69 ( Main/Exploration ); précédent : 000C68; suivant : 000C70Stem cells in development of therapeutics for Parkinson's disease: A perspective
Auteurs : Jiajie Xi [République populaire de Chine] ; Su-Chun Zhang [République populaire de Chine, États-Unis]Source :
- Journal of Cellular Biochemistry [ 0730-2312 ] ; 2008-12-01.
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Abstract
Using Parkinson's disease as a prototype of neurodegenerative diseases, we propose applications of human stem cells in the development of therapeutics for neurodegenerative diseases. First, in vitro differentiation of human stem cells offers a versatile model for dissecting molecular interactions underlying human dopamine (DA) neuron specification, which may form a foundation for instigating regeneration of DA neurons from progenitors that reside in the brain. Second, stem cells derived from diseased cells or through genetic modification can serve as a platform for unraveling biochemical processes that lead to the cellular pathogenesis of degeneration. This may in turn serve as a template for identifying or developing therapeutics for slowing, stopping, or reversing the disease process. And finally, stem cells, particularly those induced from patients' own cells, provide a reliable source of DA neurons for cell‐based therapy. J. Cell. Biochem. 105: 1153–1160, 2008. © 2008 Wiley‐Liss, Inc.
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DOI: 10.1002/jcb.21916
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Biochem.</title><idno type="ISSN">0730-2312</idno><idno type="eISSN">1097-4644</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-12-01">2008-12-01</date><biblScope unit="volume">105</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="1153">1153</biblScope><biblScope unit="page" to="1160">1160</biblScope></imprint><idno type="ISSN">0730-2312</idno></series><idno type="istex">12C37D9D6AB1E7E5A07C0A9B6C4920884EF1FC95</idno><idno type="DOI">10.1002/jcb.21916</idno><idno type="ArticleID">JCB21916</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0730-2312</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson disease</term><term>neural degeneration</term><term>stem cell</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Using Parkinson's disease as a prototype of neurodegenerative diseases, we propose applications of human stem cells in the development of therapeutics for neurodegenerative diseases. 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Biochem. 105: 1153–1160, 2008. © 2008 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Wisconsin</li></region></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Xi, Jiajie" sort="Xi, Jiajie" uniqKey="Xi J" first="Jiajie" last="Xi">Jiajie Xi</name></noRegion><name sortKey="Zhang, Su Hun" sort="Zhang, Su Hun" uniqKey="Zhang S" first="Su-Chun" last="Zhang">Su-Chun Zhang</name></country><country name="États-Unis"><region name="Wisconsin"><name sortKey="Zhang, Su Hun" sort="Zhang, Su Hun" uniqKey="Zhang S" first="Su-Chun" last="Zhang">Su-Chun Zhang</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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